Home / About StemCello / Intellectual Property
Patents and publications
The ingredients and technologies in StemCello Revitalizing™ are documented in Korean and US patents and in peer-reviewed journals. Patents describe ingredient technology and research methods; they are not claims about the finished cosmetic products.
Part 1 · Patents
Patents
Korean and US patents on stem cell research methods and on ingredients used in StemCello products.
BioSpectrum stem cell-related patents
Stem cell research patents
| Title (subject) | Patent no. | Registered | Expected expiry |
|---|---|---|---|
| Composition for promoting stem cell proliferation comprising vegetable peptone (activation of skin stem cells by vegetable peptone) | KR 10-1220239 | 2013-01-09 | 2029-03 |
| Composition for promoting stem cell proliferation comprising vegetable peptone (skin bioactivity of stem cell culture medium containing vegetable peptone) | KR 10-1181911 | 2012-09-11 | 2029-03 |
| Serum-free medium for animal cell culture comprising natural extracts or isolated compounds (thistle extract) | KR 10-1245562 | 2013-03-21 | 2030-05 |
| Serum-free medium for animal cell culture comprising natural extracts or isolated compounds (stigmasterol) | KR 10-1245553 | 2013-03-22 | 2030-05 |
| Serum-free medium for animal cell culture comprising natural extracts or isolated compounds (Acanthopanax extract) | KR 10-1245554 | 2013-03-22 | 2030-05 |
| Serum-free medium for animal cell culture comprising natural extracts or isolated compounds (N-galactosamine) | KR 10-1245557 | 2013-03-22 | 2030-05 |
| Composition for improving skin conditions comprising Andrographis paniculata extract or andrographolide | KR 10-1694958 | 2017-01-10 | 2034-04 |
| Composition for promoting the proliferation and differentiation of adipose-derived stem cells (Ulva pertusa extract and skin volume) | KR 10-2121315 | 2020-06-17 | 2037-12 |
Ingredient and material patents
Patents on ingredients used in products
| Title | Patent no. | Year |
|---|---|---|
| Composition for anti-pollution of skin comprising Camellia japonica flower extract | KR 10-1560526 | 2015 |
| Compositions for improving skin conditions comprising protocatechuic acid | KR 10-0863618 | 2008 |
| Cosmetic composition comprising asiaticoside | KR 10-0511944 | 2005 |
| Naturotics (compound natural preservative) | KR 10-0782599; US 2007/0231403 A1 | 2007 |
| A composition comprising compounds of natural origin for damaged skin | KR 10-0812596; US 7,994,141 | 2008 / 2011 |
| Multiple layered liposome and preparation method thereof (expired) | KR 10-0461458 | 2004 |
| Agents for skin whitening containing madecassoside | KR 10-1245563 | 2013 |
| Composition for anti-aging comprising extracts of Gosorisul lees | KR 10-2897735 | 2025 |
| Composition comprising white willow bark extract (dark circles) | KR 10-2874784 | 2025 |
| Composition for strengthening the skin barrier or moisturizing comprising white willow bark extract | KR 10-2962438 | 2026 |
Part 2 · Scientific papers
Scientific papers
Peer-reviewed publications on stem cell research and on ingredients applied to product development.
Scientific papers
Stem cell-related research papers
- Lee J, Lee J, Hwang H, Jung E, Huh S, Hyun J, Park D. Promotion of stem cell proliferation by vegetable peptone. Cell Prolif. 2009;42(5):595-601. doi:10.1111/j.1365-2184.2009.00630.x
- Roh KB, Lee J, Kim YS, Park J, Kim JH, Lee J, Park D. Mechanisms of edible bird’s nest extract-induced proliferation of human adipose-derived stem cells. Evid Based Complement Alternat Med. 2012;2012:797520. doi:10.1155/2012/797520
- Lee J, Roh KB, Kim SC, Lee J, Park D. Soy peptide-induced stem cell proliferation: involvement of ERK and TGF-β1. J Nutr Biochem. 2012;23(10):1341-51. doi:10.1016/j.jnutbio.2011.08.003
- Lee J, Jung E, Kim YS, Park D, Toyama K, Date A, Lee J. Phloridzin isolated from Acanthopanax senticosus promotes proliferation of α6 integrin (CD49f) and β1 integrin (CD29) enriched for a primary keratinocyte population through the ERK-mediated mTOR pathway. Arch Dermatol Res. 2013;305(8):747-54. doi:10.1007/s00403-013-1398-6
- You J, Roh KB, Li Z, Liu G, Tang J, Shin S, Park D, Jung E. The antiaging properties of Andrographis paniculata by activation epidermal cell stemness. Molecules. 2015;20(9):17557-69. doi:10.3390/molecules200917557
- You J, Roh KB, Shin S, Park D, Jung E. Andrographolide promotes the stemness of epidermal cells through the extracellular signal-regulated kinase (ERK) pathway. Kor J Pharmacognosy. 2019;50(1):18-24.
- Woo H, You J, Park D, Jung E. Protective effect of Rhus semialata M. extract on epidermal stem cells against UV irradiation. J Soc Cosmet Sci Korea. 2019;45(4):415-22. doi:10.15230/SCSK.2019.45.4.415
- Woo J, Ji H, Jeon K, Kim H, Yoon S, Hwang Y, Cho E, Park D, Jung E. Anti-skin aging effects of Gosori liquor lees extract by regulating interactions between senescent fibroblasts and adipose-derived stem cells. Int J Cosmet Sci. 2025;47(3):476-87. doi:10.1111/ics.13046
Ingredient research
Papers on ingredients applied to product development
- Effects of vegetable peptones on promotion of cell proliferation and collagen production. J Soc Cosmet Sci Korea, 2009.
- Panax ginseng induces human type I collagen synthesis through activation of Smad signaling. J Ethnopharmacol, 2007.
- Asiaticoside induces human collagen I synthesis through TGF-beta receptor I kinase-independent Smad signaling. Planta Med, 2006.
- Evaluation of the effects of a preparation containing asiaticoside on periocular wrinkles of human volunteers. Int J Cosmet Sci, 2008.
- Effect of Camellia japonica oil on human type I procollagen production and skin barrier function. J Ethnopharmacol, 2007.
- Protective effects of Camellia japonica flower extract against urban air pollution. BMC Complement Altern Med, 2019.
- Improvement of skin aging through antioxidant and cell regeneration effects of the peptide complex. J Invest Cosmetol, 2025.
- Madecassoside inhibits melanin synthesis by blocking ultraviolet-induced inflammation. Molecules, 2013.
- Isorhamnetin represses adipogenesis in 3T3-L1 cells. Obesity, 2009.
- Isorhamnetin-induced anti-adipogenesis is mediated by stabilization of β-catenin protein. Life Sci, 2010.
- Jeon S, et al. The effect of Salix alba L. bark extract on dark circles in vitro and in vivo. Int J Cosmet Sci, 2023.