FMLT: our multilamellar liposome technology

A concentrated liposome, ready to load

StemCello Revitalizing™ products utilize “Cellike”—a natural emulsifying agent composed of a precisely balanced blend of high-purity, plant-derived lecithin and carefully selected oils—in place of synthetic emulsifiers. Cellike enables the rapid formation of liposomes under atmospheric pressure, eliminating the need for expensive, specialized liposome-manufacturing equipment.

Cellike functions as a pre-formulated, highly concentrated liposome base that does not contain any active ingredients. Its high concentration allows for the creation of various formulations—ranging from lotions to creams—with little to no need for additional thickening agents. StemCello Revitalizing™ products are manufactured by emulsifying Cellike for a short duration under standard homogenization conditions (3,000 rpm), a process that results in the formation of multilamellar liposomes. Under these typical emulsification conditions, Cellike produces multilamellar liposomes with an average size of approximately 500–1,000 nm.

Emulsifier

Cellike: plant-derived lecithin + selected oils

Process

3,000 rpm homogenization at room temperature, atmospheric pressure; optional 1,000 bar pass

Mean size

≈ 500–1,000 nm multilamellar vesicles

Loading test

Protein of ≈ 20,000 Da loaded and delivered stably to the skin’s surface layers

Origin

Based on Korean patent 10-0461458 (2004), multiple-layered liposome

By enabling the creation of liposomes of a desired size using only Cellike—without the need for a high-pressure homogenizer—this approach not only reduces manufacturing costs but has also shown advantages over conventional processes in our formulation work for stabilizing volatile or unstable ingredients, such as retinol. BioSpectrum has termed this technology—which allows for the convenient, room-temperature production of multilamellar liposomes using Cellike—‘FMLT’ (Fast Multi-Liposome Technology).